Could Ozempic also fight addiction?

As semaglutide ((brand names: Wegovy, Ozempic)) has skyrocketed in popularity, patients have been sharing curious effects that go beyond just appetite suppression. They have reported losing interest in a whole range of addictive and compulsive behaviors: drinking, smoking, shopping, biting nails, picking at skin. Not everyone on the drug experiences these positive effects, to be clear, but enough that addiction researchers are paying attention. And the spate of anecdotes might really be onto something. For years now, scientists have been testing whether drugs similar to semaglutide can curb the use of alcohol, cocaine, nicotine, and opioids in lab animals—to promising results.

Semaglutide and its chemical relatives seem to work, at least in animals, against an unusually broad array of addictive drugs, says Christian Hendershot, a psychiatrist at the University of North Carolina at Chapel Hill School of Medicine. Treatments available today tend to be specific: methadone for opioids, bupropion for smoking. But semaglutide could one day be more widely useful, as this class of drug may alter the brain’s fundamental reward circuitry. The science is still far from settled, though researchers are keen to find out more. At UNC, in fact, Hendershot is now running clinical trials to see whether semaglutide can help people quit drinking alcohol and smoking. This drug that so powerfully suppresses the desire to eat could end up suppressing the desire for a whole lot more.

1,600 words: https://www.theatlantic.com/health/archive/2023/05/ozempic-addictive-behavior-drinking-smoking/674098/. If you can’t get past the paywall, send me a note.

Guy secrets

Fast and funny. I can’t (or won’t) vouch for all twenty of these, but, for example:

7. “We don’t want to tell you certain things are worrying us because we do not want you to worry too. Now there are just two people worrying, whereas before, one was worrying, and the other was happy, which is a reminder to us not to worry so much.”

14. “If it looks like I’m ignoring you, I’m probably just so deep in thought that I forgot I actually exist.”

https://www.buzzfeed.com/fabianabuontempo/guy-secrets-girls-dont-know-about

Life extension techniques (in mice)

Dr. Aubrey de Grey is a legend in the longevity field who has been steadfastly promoting the idea of life extension since well before it became mainstream. While with SENS Research Foundation, de Grey made significant contributions to geroscience, and at Longevity Summit Dublin last year, he announced the creation of his new brainchild, Longevity Escape Velocity Foundation (LEVF).

(But note that he left his previous position after being accused of sexual harassment, https://en.wikipedia.org/wiki/Aubrey_de_Grey.)

Note that this strain of mice typically lives 2.5 years, and this project wants to increase it to 3.5… but with interventions starting at 1.5 years. Thus the expected one-more-year of life would become two years.

We want to get mice to live a lot longer than they do now: at least a year longer, starting the treatment or treatments only after middle age. The idea is that this will appeal more directly to people who care, vote, pay taxes, and make donations than if you do early-onset interventions. So, I decided to put numbers on this, to have a milestone that clearly says this is where we want to get to. We believe this will be a sufficiently dramatic result….

There’s a control group that gets nothing, and there’s also a group that gets all four of our interventions, but there are also four groups that get exactly one intervention, so that we have some kind of baseline. And then we have four groups that get three out of the four. This is very important. The purpose of this is to determine whether there are antagonistic interactions between things, which is possible….

Starting late means that the overall experiment will take two years rather than four years. But the other one, which is just as important, is that because we are mostly doing rejuvenation therapies that remove damage rather than just slowing down the creation of new damage, we have a good chance of seeing they’re working from the divergence of survival curves quite quickly, like after only six months.

4,500 words: https://www.lifespan.io/news/aubrey-de-grey-on-levf-and-robust-mouse-rejuvenation/.

Carlos Santana and Rob Thomas: Smooth

I don’t think this will date me, because Smooth is still around. This article covers the idea behind, and the making of, one of the biggest songs of the 1990s. Santana hadn’t scored a hit single in more than 15 years. Part Latin-rock jam, part devotional love song? It almost didn’t happen.

Rob Thomas, who wrote the lyrics, says:

The (original) song was a different song. It was all about some party going on in a room. My wife [Marisol, then his fiancée; the two married in late 1999] went off for the afternoon and I stayed at home. I think the “smooth” part came first. I was thinking more about Carlos. I was thinking, “You’re so smooth,” about Carlos Santana. And then, “You hear my rhythm on your radio.” But then, I also realized somewhere in the middle of it that I had this wealth of information because I had this smokin’ hot Latin girlfriend already. Even though she was from Queens and not Spanish Harlem, everything else was on point, and it ended up being about her.

And:

The challenge was, “How do I create a believable conversation between Carlos and Rob?” Editing was a crucial part of that. Generally, the guitar doesn’t play when Rob sings. And that was really part of the trick of it. There are one or two notes where they land together in harmony, and then they get out of each other’s way. That was designed into the arrangement of everything.

Fights about the rights. Convincing Santana. Fascinating story about how a classic song developed: https://www.rollingstone.com/music/music-features/santana-rob-thomas-smooth-oral-history-841189. About 7,200 words.

Ordinary Iranians and the protests

In an authoritarian state such as Iran, protesting against the government can get you arrested, tortured, or even killed. Much of the population is afraid of that, of course. And yet, many have found a role in assisting without exposing themselves too much:

Apart from the two sides, on what everyone knows is a battlefield, a bigger group nonetheless circulates—an almost unending sea of young families, elderly couples and passersby, some just walking up and down the street, some sitting in their cars in the traffic. They are not shouting any slogans, not protesting anything, yet they brave the tear gas, the charges by security forces, the shouts to move along. They act as if it were just another evening and they’re out for a spin on the streets, window shopping, but they’re also giving cover to protesters—to disappear among them, or hop onto cars, or into shops, to escape the frenzied charges of security forces…

Every night at 9:00 the shouts begin. From rooftops, balconies, and windows of dark rooms, women and men, and sometimes even children, huddled into the dark recesses to avoid inquisitive eyes, shout “Zan, Zendegi, Azadi” (Woman, Life, Freedom), followed by “Death to the Islamic Republic” and “Poverty, Corruption, High prices, Onwards to the Overthrow.” It started days after Mahsa Amini died in police custody, at age 22, arrested for how she wore her headscarf. Sometimes the chanting goes on for an hour.

About 2,600 words: https://time.com/6275538/iran-protests-eyewitness-report.

Also, this site https://www.understandingwar.org summarizes the Iran situation daily (as well as the Russian invasion of Ukraine). Click on the headline, such as Iran Update, May 2, 2023, to see the full daily report.

Every tech support task you should do for your family

How to save money, prevent hacks and make everything work smoothly.

Like getting your teeth cleaned or emptying the gutters, there are a number of digital maintenance tasks everyone should see to once or twice a year.

  • Update all the software.
  • Make sure contact emails are up-to-date.
  • Turn on two-factor authentication.
  • Set up a password system.
  • See if the storage is full.
  • Set up automatic backups. (In my opinion, this should be the very first priority.)
  • Adjust accessibility features.
  • Scan for any malware or adware.
  • Cancel unwanted subscriptions.
  • Organize cable and streaming services.
  • Check the cable, Internet and phone bill.
  • Add legacy contacts.
  • Lock down all the privacy settings.
  • Set up computers so you can help remotely.
  • Find local tech support.
  • Clear out old unwanted tech.
  • Set up any holiday tech gifts.
  • Review common scams.

Each of these tips has an explanation of why it’s important and how to do it. Yes, it’s a lot of items, but doing as many as you can will help, and you can do (for example) one item a week. 1,600 words: https://www.washingtonpost.com/technology/2021/12/20/tech-support-checklist/.

How a shipping error launched the chicken industry

In 2020 alone, people around the world consumed over 70 billion (chickens), up from 8 billion in 1965…

The story begins 100 years ago in 1923, with homemaker and farmer Cecile Steele of Ocean View, Delaware. Steele, like many other rural Americans in her time, kept a small flock of chickens that she raised for eggs and waited to slaughter them for meat once their productivity waned. But one day by accident the local chick hatchery delivered 500 birds, 10 times more than the 50 Steele had ordered

Five hundred hens was a lot — bigger farms at the time had only 300.

The discovery of Vitamin D, which when added to chicken feed helped chickens survive a winter inside a barn, also made a big difference.

https://www.vox.com/future-perfect/2023/2/10/23589333/cecile-steele-chicken-meat-poultry-eggs-delaware. 2,665 words.

Anti-aging vaccine shows promise (in mice)

I’m still tracking progress in life elongation. Here’s a result from 2021:

An experimental vaccine successfully eliminated aging cells from the bodies of mice, helping to prolong the rodents’ lives and reverse some signs of age-related disease…

The new vaccine targets senescent cells, which are cells that have stopped multiplying due to damage or stress, but don’t die when they should…. These cells accumulate as we age, as the immune system becomes less efficient at clearing such cells from the body. Senescent cells release compounds that trigger inflammation and thus damage nearby healthy cells. And evidence suggests that this buildup of senescent cells contributes to a slew of age-related diseases, including cancer, Alzheimer’s and atherosclerosis, a disease where plaque builds up in the arteries.

For the past decade, scientists have been working to develop “senolytic therapies,” or drugs that can clear senescent cells from the body. Some of these drugs have reduced inflammation, delayed the onset of age-related diseases and extended the life span of rodents. A couple dozen of these drugs have entered clinical trials in human patients…

To see if the vaccine showed any effect on general signs of aging, the team vaccinated middle-age mice, a little over a year old, and then tested their agility at about 1.5 years old. Mice given a placebo shot moved less often and more slowly in their old age, but mice given the vaccine remained far more spry, the team found. What’s more, in a third experiment, the team found that mice given the vaccine lived slightly longer than mice given the placebo, hinting that the shot may somewhat prolong life span.

The team didn’t notice any side effects in their vaccinated mice.

1,200 words: https://www.livescience.com/vaccine-against-aging-senescent-cells-in-mice.

Lawsuits against fossil fuel industry

In 2005, I was the lead counsel on behalf of the US in one of the biggest corporate accountability legal actions ever filed. That trial proved that the tobacco industry knew it was selling and marketing a harmful product, that it had funded denial of public health science, and had used deceptive advertising and PR to protect assets instead of protecting consumers.

Today, the fossil fuel industry finds itself in the same precarious legal position as the tobacco industry did in the late 1990s. The behaviour and goals of the tobacco and petroleum industries are pretty similar – and there are many similarities in their liabilities.

Both industries lied to the public and regulators about what they knew about the harms of their products. Both lied about when they knew it. And like the tobacco industry while I was in public service, the deceptive advertising and PR of the fossil fuel industry is now under intense legal scrutiny.

And the tide is beginning to turn. More than 1,800 lawsuits have been filed over climate liability worldwide.

Full article (890 words): https://www.theguardian.com/commentisfree/2022/jul/05/us-lawsuit-big-tobacco-big-oil-fossil-fuel-companies