COVID versus cancer (in mice)

During the pandemic, some doctors anecdotally began noticing that some people with cancer who got very sick with COVID-19 saw their tumors shrink or grow more slowly…

Typically, monocytes, as part of the immune system, cruise the bloodstream and alert other immune cells to the presence of foreign cells or pathogens; some monocytes can attract cancer-killing immune cells to tumors, but others aren’t as effective in doing so. That’s because in some cases, cancer cells can co-opt monocytes —“like a demon summoning forces” —and form an immune wall protecting the tumor from being discovered and attacked by additional immune defenses.

But during a COVID-19 infection, SARS-CoV-2 attaches itself to these monocytes, and by doing so reverts them back to doing their original job: defending the body against cancer…

By analyzing the receptor on the monocytes that the COVID-19 virus attached to, Bharat found a compound that currently isn’t used to treat any disease but is a close mimic of the COVID-19 virus in the way that it binds to the monocyte to induce the cell’s transformation into a cancer-fighting cell…. In animal tests, the compound—called muramyl dipeptide (MDP)—reduced tumors by 60% to 70% in mice with human cancers including breast, colon, lung, and melanoma.

Full article: https://time.com/7176558/covid-19-virus-cancer-monocytes/ (approx 763 words).

And good news from Fix the News:

The EU is in the midst of finalizing a plan to completely end imports of Russian fossil fuels; the European Commission first pledged to quit Russian fossil fuels in 2022 as a response to Moscow’s invasion of Ukraine. The imports won’t completely end until 2027, but in the meantime, Czechia has achieved full independence from Russian oil for the first time in its history; the country now receives no supplies through Russia’s Druzhba pipeline, ending a 60-year dependency. This is significant because Czechia previously received half its oil from Russia and had an EU exemption from the 2022 Russian oil ban.

Universal Basic Income (UBI) #2

A German experiment has found that people are likely to continue working full-time even if they receive no-strings-attached universal basic income payments.

Universal basic income, also known as guaranteed income, is the idea of giving money to everyone regardless of how much they already earn – to give them the freedom to move between jobs, train for new positions, provide care, or engage in creative pursuits….

Unlike the control group, those receiving a basic income were more likely to change jobs or enroll in further education. They reported greater satisfaction in their working life – and were “significantly” more satisfied with their income.

Full article (900 words): https://www.cnn.com/2025/04/11/health/germany-universal-basic-income-study-intl-scli-wellness/index.html. Also see https://laughlearnlinks.home.blog/2022/11/10/universal-basic-income-ubi/.

And good news from Fix the News:

The just-released 2025 Annual Report to the Nation on the Status of Cancer reveals cancer mortality in the United States declined by 1.5% per year between 2018 and 2022, painting an encouraging picture of progress against America’s second-leading cause of death.
– Lung cancer showed the steepest decline with death rates dropping 4.5% annually among men and 3.4% among women.
– Childhood cancer mortality continues to decline at 1.5% annually.
– Overall cancer death rates have decreased by over 33% since 1991 (and no.. it’s not just because people have stopped smoking).

The Roman way to trash a republic

“When you’re the emperor Augustus, they let you do it.”

The Roman Republic lasted nearly 500 years, about twice as long as Americans have had theirs. As was surely true for the Romans, most Americans can hardly imagine that their system of self-government might break and be replaced by an imperial dynasty. That is why considering what undid the Roman Republic is useful today—if we can learn from the Romans’ mistakes.

Augustus was Rome’s first emperor. In so becoming, he dismantled the republic and founded a monarchy that would last for more than a millennium. In Rome, most aristocratic men were also senators and usually held that position for life. In the later republic, some of those men—notably, Julius Caesar, Pompey, and Crassus—grew so extraordinarily rich and influential that they began to ignore the constraints of the Senate and the law. In the first century B.C.E., decades of aristocratic overreach and the authoritarian violence of Augustus’s predecessors Sulla and Caesar brought Rome to the brink more than once, but Augustus pushed it over the edge.

Full article: https://www.theatlantic.com/ideas/archive/2025/04/rome-senators-republic-augustus/682469/. Approximately 1,250 words. Contact me if the article is blocked by a paywall.

And good news from Fix the News:

Solar and battery prices keep on falling… solar panel prices dropped 37-46% and batteries fell by 20% last year. This cost reduction drove nearly 600GW of global solar installations, with 700GW expected this year and 1,000GW annually by 2030. Solar manufacturing capacity is now three times current global demand, while 30% of all new battery storage is getting paired with solar, an irresistible combination. Renew Economy

Chicken Little: The Sequel

You know the story of Chicken Little. An acorn fell on her head in the forest, and she thought the sky was falling, and she frightened all the other animals into fearing that the sky was falling. It ended badly.

I found a sequel to this story:

Foxy Loxy is walking along the forest path. He is surprised to see Chicken Little lying in the path on her back, feet pointing at the sky.

Foxy Loxy asks, “Chicken Little! What are you doing?”

Chicken Little replies, “You know that the sky is falling, right?”

Foxy Loxy says, “Yes yes yes, we all know that. But what are you doing there?”

“I’m going to try to hold up the sky.”

“But Chicken Little — you’re just a little chicken! You can’t hold up the sky!”

And Chicken Little replies, “Yes, I know. But you do what you  can.”

❖❖❖

And good news from Fix the News:

In 2019, Iceland became one of the first countries to implement a four-day workweek. Today, nearly 90% of Icelandic workers have shifted from a 40- to 36-hour workweek, with no loss in pay. Six years later, research indicates that productivity remained stable or even increased in some sectors, all while workers reported better mental health. Parents reported more equal household sharing responsibilities. WEBC

AI against cancer?

This article does a nice job explaining cancer and our techniques to fight it, and how AI (in its early forms) can help find more techniques:

Digesting reams of CODEX data is where artificial intelligence comes in. AI is quickly becoming a central tool in cancer research. AI could identify which cells, or combination of cells, are associated with patients who respond to treatments and patients who do not respond to them. It could then suggest solutions—and even design drugs that eliminate whatever it is that is preventing a patient’s immune system from defeating the cancer.

Full article is at https://www.newsweek.com/2023/12/08/ai-cancer-fighting-tool-weve-been-waiting-1845842.html. About 4,200 words, but covers a lot of territory.

And good news from Fix the News:

Every generation in the United States has a lower risk of dementia than the last. While previous projections estimated U.S. dementia cases would double by 2050, a new analysis finds that age-adjusted prevalence has dropped by 67% over the past 40 years. If this trend continues, total cases may rise by only 25% instead of doubling. ALZFORUM

Cute animal photos

Need I say more?

https://www.theguardian.com/environment/gallery/2025/mar/21/week-in-wildlife-march-hares-a-dreaming-dormouse-and-the-first-chicks-of-spring.

And good news from Fix the News:

Mexico City changes bullfighting rules to preserve the spectacle but save the bulls: The biggest bullfighting city in the largest bullfighting country in the world is making a change to its centuries-old custom: from now on bullfighters will only be allowed to use capes (no swords!) and fights will be capped at 15 minutes. The shift is designed to protect the bulls while retaining the spectacle (and livelihoods!) of those that rely on the games. Mexico News Daily

Seventeen life hacks

Cheap little tricks that may make a nice difference. For example:

That’s where it goes:

“If you look for something and it’s not in the first place you look, THAT IS THE PLACE WHERE IT GOES. So when you find it, put it in the first place you looked for it.”

Also: How to argue (from a lawyer); buy the same socks; the restaurant bathroom test; how to talk to new people, etc.

Article: https://www.upworthy.com/17-life-hacks-that-are-so-good-people-almost-didn-t-want-to-share-but-thankfully-they-did-ex1.

And good news from Fix the News:

After being named “breakthrough of the year” by Science magazine in 2024, the HIV drug lenacapavir continues to improve. New Phase I trials show the drug maintains protection for a full year after a single dose.The previous twice-yearly formulation has already demonstrated unprecedented 100% effectiveness in preventing infections and its maker Gilead has arranged to make affordable versions accessible across 120 low-income countries. Oh, and The Global Fund says it will fund the rollout of lenacapavir with or without the help of the US government.MITBhekisisa

Movie bloopers

…by extras, that somehow made it into the final film: https://www.youtube.com/watch?v=UVLq3xSClQA (8 min 25 seconds plus grrr commercials). Includes the famous Storm Trooper hitting the top of a door frame with his helmet:

And good news from Fix the News:

In the past five years, over 100 million people in Africa have gained access to electricity. Liberia has seen access go from 5% in 2017 to 35% today, Rwanda has gone from 6% in 2009 to 75% today, Nigeria is now at 70%, up from 50% a decade ago, Gabon and Equatorial Guinea have reached 90%, and Rwanda, Senegal and Kenya are all targeting universal access by 2030. Global Energy Prize

⚡ Those may seem like dry numbers but it’s life-changing stuff; for a vivid look at how lives change when people gain access to electric power, check out Robert Caro’s piece on pre- and post-electricity life in 1930s rural Texas in “The Sad Irons.

Dino-killing ourselves

I found this description of how much energy we’re putting into our planet from fossil fuels:

Our addition of the greenhouse gases into the atmosphere is the long lever that can move the world. Between 1970 and 2020, 381±61 zetta joules (10^21 joules) of additional energy was absorbed into the system (i.e. the Earth).

This estimate was prepared using satellite data, which is public source, https://essd.copernicus.org/articles/15/1675/2023/

How much energy is this? It’s roughly 80% of the estimated energy of the Chicxulub impactor. Albeit spread over a significantly longer period of time.

The strongest explosion humanity has ever created is in the order of 10^17 joules, or a hundred quadrillion joules.

We’ve managed to add 1.5 million times that number in this 50 years. We’ve been essentially adding one Tsar Bomba’s worth of energy ((approx 50 megatons)) every fifteen to twenty minutes for the past five decades.

The Chicxulub meteor impact blew away roughly half a continent, and the resulting climate change wiped out all the dinosaurs except for birds. We’re doing the same thing to ourselves, spread out a bit but… that’s a lot of energy to be not thinking about. Yeesh.

Original: https://news.ycombinator.com/item?id=42676838.

And good news from Fix the News:

Major wins for U.S. rape kit reform. In 2016, the Joyful Heart Foundation developed an actionable nationwide campaign to end the backlog of untested rape kits across the United States. As of January 2025, 21 states and Washington D.C. have achieved full rape kit reform, benefitting 163.4 million people. Two recent, big wins occurred in New Jersey and Pennsylvania, which both implemented a rape kit tracking system in 2024. End The Backlog

The dictator myth that refuses to die

Admiration for autocracy is built on a pernicious lie that I call the “myth of benevolent dictatorship.” The myth is built on three flimsy pillars: first, that dictators produce stronger economic growth than their democratic counterparts; second, that dictators, unswayed by volatile public opinion, are strategic long-term thinkers; and third, that dictators bring stability, whereas divided democracies produce chaos….

Let’s start with the myth that dictatorships produce stronger growth. This falsehood arose from a few well-known, cherry-picked examples, in which despots oversaw astonishing transformations of their national economy…. But a systematic evaluation of the overall data reveals another reality. Even with these outliers of strong growth, most rigorous studies have found limited or no evidence that authoritarian regimes produce better economic growth than democratic ones… However, the myth of strongmen as economic gurus has an even bigger problem. Dictators turn out to have manipulated their economic data for decades. For a long time, they’ve fooled us. But now we have proof: The reason their numbers sometimes seem too good to be true is that they are…. the notion that Benito Mussolini made the trains run on time was a lie; he built ornate stations and invested in train lines used by elites, but the commuting masses got left behind.

The myth’s second pillar turns out to be no less rickety than the first. It holds that dictators are more strategic long-term thinkers than democrats because they’re not beholden to fickle public opinion. But this lie is believable only if you don’t understand how most dictatorships actually work. ((more details))

The most persistent pillar of the myth, however, is the one that holds that dictators produce stability… Eventually, though, dictatorships tend to fall apart. And when they collapse, they really collapse. Elections in democracies change governments, not regimes. Personalist dictatorships, by contrast, often implode. ((more details)

Approx 2,100 words: https://www.theatlantic.com/international/archive/2023/07/authoritarianism-dictatorship-effectiveness-china/674820/.

And good news from Fix the News:

Europe’s wild predators stage a stunning comeback. Since 2016, golden jackal numbers have surged by 46% to 150,000, wolves have increased by 35% to 23,000, brown bears by 17% to 20,500, and Eurasian lynx and wolverine populations expanded by 12% and 16% to 9,400 and 1,300 animals respectively. The best recovery? Iberian lynx numbers are up from 100 at the turn of the century to over 2,000 today. Guardian